发给老马备查:
* p1 X+ U2 c+ ^6 p) V滴水察海(69304838) 15:23:237 F% M, g k+ ?8 }
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱9 Q: ~: K s/ G# i. ]5 ~, a
吉非替尼和S-1连用的依据
% l) |6 h7 z5 V3 M( {6 ], bGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
: A3 E. B, s: u) d是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
4 y4 a! i+ A" d6 z这样是不是推理出,耐药后,可以用S-1和培美了?( X/ V6 l$ y! u6 D
结论:7 [$ G4 M' I$ A
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |