发给老马备查:) f- K: q% U! A9 O' F/ `
滴水察海(69304838) 15:23:23
" J; i. l, q1 v ]* Q2 W& O5 w v; c老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
* O+ `/ a6 M" Y9 m吉非替尼和S-1连用的依据$ J; i) [0 y& `0 `/ W& l, a
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
9 H) L) A1 B M* z! u# _8 b是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
3 U/ p% q* g+ J7 C5 F这样是不是推理出,耐药后,可以用S-1和培美了?% X. V) G# I# v5 R
结论:
) [4 A9 K w: ~+ y0 g7 x8 _如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |