发给老马备查:' f) I. b. K; M! o4 @
滴水察海(69304838) 15:23:23 U* }$ C6 f6 A; N/ x2 I' k4 w0 T; M
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱3 b8 y' v: W, g V- r5 _* d* F# Z
吉非替尼和S-1连用的依据) l( H1 B4 ~. Y$ s) p6 W1 w9 ^' B3 V
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro." o4 t4 p1 V/ }7 x) x) D1 B, b; Q
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
3 M! {0 }' Q- h9 P这样是不是推理出,耐药后,可以用S-1和培美了?
, g# P" X- A2 i8 i7 B7 Y结论:0 i3 F, n1 f0 H5 e; N Z+ W/ ~
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |