发给老马备查:
' i- y1 \+ m; J. w4 p4 T滴水察海(69304838) 15:23:23
3 K/ @! i) g3 L0 {; [老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
2 X8 f& E. y% O( `5 @4 }吉非替尼和S-1连用的依据
) E: I5 e2 H' C" Z9 ^/ t( K3 h! wGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.9 H# I5 _, h/ r8 W9 h0 c. @
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
, c1 G' W8 e" F2 t1 D& J这样是不是推理出,耐药后,可以用S-1和培美了?
2 Y3 K8 C% P& H% U) W6 y4 E0 Z: u结论:
9 w: T- b" q @: l `% H* h. Z如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |