发给老马备查:8 ]* b, Z$ [' V- q. z; H
滴水察海(69304838) 15:23:23
/ _! ]/ y+ f/ Q: F老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
, Z' o0 e% e9 L: ~# W5 p: a1 O吉非替尼和S-1连用的依据
; S$ o4 G8 A8 ~; I9 n! _Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.5 d1 }1 s% p! W; ^$ R, n+ l
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达& ^- h5 t$ f! j% G9 |, v
这样是不是推理出,耐药后,可以用S-1和培美了?
/ A- t' @7 |7 e1 W! E1 r5 p1 X! Q6 T结论:6 T* Y/ Q4 q+ x4 K# G/ M
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |