发给老马备查:5 [. ?- v w! A- @+ w, ~$ B# b
滴水察海(69304838) 15:23:239 H% }( E; L) m: y0 [( q2 m- A# a
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱- o5 @# y; a* e& o( ^6 G- z
吉非替尼和S-1连用的依据
, a! U: c$ V1 t, ?/ Y9 h' H1 hGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
8 {: A, Y+ @- }: U是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达! D) c: n% Y7 I- G2 p
这样是不是推理出,耐药后,可以用S-1和培美了?
4 W/ \# j: m c1 w" X& t; T结论:& h6 |% P8 j" i" n# w3 }
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |