IL-2联褪黑素化疗后维持治疗结肠癌的，比没有维持治疗的提高了一年生存率，部分病人维持治疗时肿瘤继续退缩。
http://www.ncbi.nlm.nih.gov/pubmed/7715908
A randomized study of low-dose subcutaneous interleukin-2 plus melatonin versus supportive care alone in metastatic colorectal cancer patients progressing under 5-fluorouracil and folates.
Abstract
Chemotherapy with 5-fluorouracil (5-FU) and folates represents the first-line standard therapy for metastatic colorectal cancer, whereas at present there is no conventional second-time treatment. Because of its importance in generating an effective anticancer immune response, interleukin-2 (IL-2) could constitute a new promising therapy of advanced colon cancer. Generally, IL-2 may determine tumor regressions in colon cancer only when it is given at high toxic doses. Our preliminary studies have shown that the pineal hormone melatonin may amplify IL-2 activity, which becomes active also at low doses in several tumor histotypes. On the basis, we have performed a clinical trial to evaluate the impact of low-dose IL-2 plus melatonin on the survival time in metastatic colon cancer, which progressed in response to 5-FU plus folates. The study included 50 metastatic colorectal cancer patients, who did not respond or progressed after initial response to first-line chemotherapy with 5-FU and folates. Patients were randomized to receive supportive care alone or low-dose subcutaneous IL-2 (3 million IU/day for 6 days/week for 4 weeks) plus melatonin (40 mg/day orally). No spontaneous tumor regression occurred in patients receiving supportive care alone. A partial response was achieved in 3/25 patients treated with immunotherapy. Percent survival at 1 year was significantly higher in patients treated with immunotherapy than in those treated with supportive care alone (9/25 vs. 3/25, p < 0.05). This study suggests that low-dose subcutaneous IL-2 plus melatonin may be effective as a second-line therapy to induce tumor regression and to prolong percent survival at 1 year in metastatic colorectal cancer patients progressing under 5-FU and folates.
|
EGFR19奥西替尼六个月影像进展求助
求助一下论坛的各位朋友，我父亲6月背痛住院，检查出来肺腺癌四期，伴随骨转移和淋巴
【跨越五年】可能是最轻松治疗的肺癌
转载自：Mia和小怪兽
现在刚好距离我爸发现肺癌过去五年了，跟大部分患者比，我爸应
我父亲的情况能否免疫治疗？
父亲因胸痛检查发现鳞癌，其中含有支气管炎和慢性阻塞性肺病 我看到网上资料说 肺炎的
请教一下基测无靶、免疫高表达后面的
治疗历程
1.治疗历程中的病情描述的变化都是基于第一次，变化于前一次的。
2.检查报告
单免坚持三年多 耐药换化疗➕免疫
自21年开始查出肺鳞癌 淋巴结转移 基因检测TP S100% 单免用了信迪利 一开始效果真好
显身卡
