看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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/ g: [$ `2 i6 J: B0 f( @Currently available feasibility data for possible combination strategies. d: B4 {. I3 A2 ~" a7 K4 T
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Combination Feasibility according to preliminary data & @* ~& h7 P; E% n @* e( G7 B
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( K" i$ r/ z; b: s! ] fBevacizumab + sorafenib Yes, reduced dose 7 ? t6 ]4 n7 l! W, @
Bevacizumab + sunitinib† No
N/ A8 k/ k K/ S: O- qBevacizumab + temsirolimus Yes
; |3 z2 @# `9 _* EBevacizumab + everolimus Yes / l2 V8 I/ i6 D
Sorafenib + sunitinib ?
0 Y5 P. H8 I! V2 m. X6 dSorafenib + temsirolimus Yes, reduced dose 2 ] V& y3 ?, y: \
Sorafenib + everolimus Yes, reduced dose
4 i# H7 b5 m; w3 q; ~% g% ?' E' G! zSunitinib + temsirolimus† No 0 ~ A8 v' E. i0 K# F3 s
Sunitinib + everolimus ? $ Q$ l! }( a+ Q9 v) o e; m
Temsirolimus + everolimus ? ; g: G$ S9 @' ]" C$ A
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2 u }! s8 \3 t* v6 w# }†Led to US FDA warning.7 d9 ^# L5 U/ i/ X; _6 B/ k
?: As yet unattempted combination.; _' u" @ }, l- n {6 a
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