看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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+ N# w) v# u$ ~# \' m% i3 {Currently available feasibility data for possible combination strategies. 4 K( C4 O* B* f9 \; G4 e
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$ B# A. {9 z$ y9 m: _2 ~3 Q/ i$ nCombination Feasibility according to preliminary data ' w. @" [, Z E( t# c
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Bevacizumab + sorafenib Yes, reduced dose
8 S; U, J2 J( y% wBevacizumab + sunitinib† No 9 }2 M* z" u$ {) z
Bevacizumab + temsirolimus Yes
9 p7 U7 a3 O! w9 D, m$ U3 dBevacizumab + everolimus Yes 6 W% }* B' b% @' z% f% g% b
Sorafenib + sunitinib ? 7 O+ W! r/ [- Y# w' w: z6 f
Sorafenib + temsirolimus Yes, reduced dose 6 Q+ F, {9 |( l
Sorafenib + everolimus Yes, reduced dose - b- m; M. N5 j: E6 N9 s
Sunitinib + temsirolimus† No / P8 z$ r4 E3 V+ T1 a1 z" P
Sunitinib + everolimus ?
- n) [; B3 a( g% |+ h5 D7 v: C0 bTemsirolimus + everolimus ? - a2 m7 Q0 Z' V- ^
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' m6 U$ @' |# k8 m2 H†Led to US FDA warning.$ x2 r7 j, a' [+ c6 N8 T0 B5 m
?: As yet unattempted combination.- s- z9 G- h0 @ h! S2 o; Q
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